Assessment of high on-treatment platelet reactivity in patients with ischemic heart disease: concordance between the Multiplate and VerifyNow assays.
نویسندگان
چکیده
L . CONSUEGRA-S ANCHEZ ,* R . L OPEZ-PALOP ,† P . CANO, P . CARR ILLO,† F . P IC O,* M. V ILLEGAS ,* J . SANCHIS‡ and J . C . KASK I§ *Cardiology Department, Hospital Universitario de Santa Lucia, Cartagena, Murcia; †Cardiology Department, Hospital Universitario de San Juan, Alicante; ‡Cardiology Department, Hospital Clinico de Valencia, Valencia, Spain; and §Cardiovascular Research Centre, St. George’s University of London, London, UK
منابع مشابه
Comparison of different methods to evaluate the effect of aspirin on platelet function in high-risk patients with ischemic heart disease receiving dual antiplatelet treatment.
Patients with coronary artery disease (CAD) receiving aspirin therapy with a residual platelet reactivity (RPR) may be at increased risk of ischemic vascular events. Point-of-care (POC) methods PFA-100 (Dade-Behring, Marburg, Germany) and VerifyNow (Accumetrics, San Diego, CA) assays have been suggested as rapid tools to evaluate RPR. We compared PFA-100 closure times by collagen/epinephrine an...
متن کاملClopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate.
BACKGROUND AND PURPOSE Clopidogrel resistance is blamed for thromboembolic complications in neurovascular stent placement. Platelet-function assays are weakly standardized. The aim of this study was to correlate the results of 3 different platelet-inhibition measurements (from light transmission aggregometry, the VerifyNow P2Y12 test, and the Multiplate analyzer) and their relation to periproce...
متن کاملPharmacodynamic Comparison of Prasugrel Versus Ticagrelor in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease: The OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus)-4 Study.
BACKGROUND Patients with diabetes mellitus (DM) are at increased risk of atherothrombotic events, underscoring the importance of effective platelet inhibiting therapies. Prasugrel and ticagrelor reduce thrombotic complications to a greater extent than clopidogrel. Subgroup analyses of pivotal clinical trials testing prasugrel and ticagrelor versus clopidogrel showed DM patients to have benefits...
متن کاملPlatelet reactivity assessment with VerifyNow®: substitute or complement for light transmission aggregometry?
Platelet aggregation inhibition is mandatory for patients undergoing percutaneous coronary intervention (PCI) [1]. High on-treatment plate-let reactivity is an important independent risk factor for the occurrence of thrombotic and ischemic events after PCI [2]. Some point of care platelet aggregation assays are currently used in daily practice as a substitute for more expensive and time consumi...
متن کاملDetermination of the prevalence of aspirin and clopidogrel resistances in patients with coronary artery disease by using various platelet-function tests.
BACKGROUND Dual therapy with aspirin and clopidogrel has emerged as the gold standard therapy for patients treated with drug-eluting stents (DES). However, there is variability in patients' responses to this antiplatelet therapy, and some patients continue to show ischemic recurrences after therapy. The purpose of the study was to compare the simultaneously obtained results of various platelet-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of thrombosis and haemostasis : JTH
دوره 11 2 شماره
صفحات -
تاریخ انتشار 2013